Recently I have been getting more and more into tweetdeck. And I have discover a couple of features that are off the default which you may like.
1- twitter name autocomplete: When you type @ a popup will show you the full list of people you follow. (Preferences -> General)
2- Auto include hash tags: this is very handy for replying to people, to maintain the conversation for people watching the hashtag. You can also edit them so no big deal. (Preferences -> General)
3- Mark Updates as Read when moving with the keyboard: this one is awesome because you can read faster and then just click “Clean seen updates” (Preferences -> General)
4- open profiles in webpage: IMO this makes things faster as the AIR client is super slow for loading those, not sure why… (Preferences -> General)
5- Max. number of updates per API call , set it to 200 this way very busy columns will not cut off (Preferences -> Twitter)
6- Max. number of updates in column, set it to 1000 this way you can let the tweet pile up for some time and catch up later, very good for when you are busy and can’t see the tweets, the default of 200 is too little specially for “trending searches” (Preferences -> Twitter)
7- enable facebook account, hey at least you will read it from here.
Another thing I really like is to have the Mentions and Direct Messages as my first two columns this way you can reply faster, perhaps I should do a post on how to organize your columns